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Cartherics Pty Ltd, a biotechnology company developing immune cell therapies for the treatment of cancer, has executed an option agreement to evaluate intellectual property (IP) from The Ohio State University (Ohio State) covering tissue factor (TF) as a target for chimeric antigen receptor (CAR) natural killer (NK) cells. The Company will utilise its proprietary induced pluripotent stem cell (iPSC)-derived NK cells to conduct the evaluation. Subject to the results, Cartherics will then exercise the option to negotiate a commercial licence to the IP.
TF is a coagulation factor that is aberrantly expressed in a range of tumor tissues and tumor blood vessels. Dr Zhiwei Hu, the inventor of the Ohio State IP, is an expert on TF cancer biology and has extensive experience in developing products targeting TF expressed in cancer tissues. Dr Hu has demonstrated that an NK cell line (NK92) carrying a CAR targeting TF is extremely effective in killing tumours in mouse models, including triple negative breast cancer (TNBC) and multiple myeloma (MM), representing a solid cancer and a hematologic malignancy that are very poorly treated using existing therapies.
“It is important that Cartherics is moving this research forward. It has the potential to open new doors for treating not only TF-positive solid cancers and hematologic malignancies, but also for treating other human diseases in which TF is highly expressed in specific diseased tissues,” said Dr. Hu, associate professor of surgical oncology in the Department of Surgery at The Ohio State University College of Medicine and a member of the Translational Therapeutics Program at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.
Cartherics will generate CAR constructs based on the Ohio State IP and insert them into its iPSC-derived NK cells. The resultant TF CAR-NK cells will then be assessed for in vitro and in vivo efficacy against relevant human cancer cell lines.
Cartherics’ CEO, Prof. Alan Trounson AO, commented: “We are delighted to be working with Ohio State to explore tissue factor as a target for our CAR-NK platform. Tissue factor represents a new tumour target for Cartherics, complementing and expanding the extensive work we’ve done with TAG-72, the target for our lead product, CTH-401.”
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