Holista CollTech (ASX: HCT) has filed a global patent for platform technology that will deliver many fat-soluble medications by creating a water-soluble delivery system.
Project leader and head of Holista’s Technical Advisory Panel, Dr Roscoe Moore Jr, said the patented process can apply to a whole range of molecules including the Cannabidiol (CBD) oil industry.
Dr Moore is the retired Assistant Surgeon General of the United States. He currently sits on several company boards linked to CBD in the United States and Canada.
“The commercial benefits for the CBD producers include making their CBD formulation up to 40 times more potent (allowing them to reduce their dosages significantly) as well as making their product palatable for the young and the elderly,” Dr Moore said.
“Fat-soluble molecules have poor bioavailability as they don’t dissolve well and reach the bloodstream. As such, a higher dosage needs to be ingested. This is both wasteful and costly.”
He added that the platform technology will particularly benefit the Cannabidiol (CBD) oil industry where the active material is scarce, costly and poorly water-soluble.
Working on developing this technology is exciting. Most medicine consumed orally is wasted due to its poor absorption by the body,” Dr Moore said.
“This is especially true for CBD, which is also expensive. More important, the integrity of the final molecule is preserved exactly as it is found in nature and hence, there is no apparent need for any lengthy approvals process anywhere in the world.
“We only use materials certified as ‘Generally Regarded as Safe’ (GRAS) by the FDA.”
CBD Oil has an earthy, musky and lingering bitter taste due to the high concentration of organic compounds that make it very unpalatable. This makes formulating CBD for oral consumption difficult.
Dr Swanand Malode, leader the Holista teams in Europe and Asia says the taste masking technology linked to this patented formulation used GRAS botanicals to allow wider applications in pharmaceutical and food with oral dosing.
“Holista drew from parallel work done on the turmeric molecule which is also very fat soluble” said Dr Swanand Malode, leader the teams in Europe and Asia that worked on this technology for more than five years.
Holista is focused on fat-soluble substances such as CBD, curcumin and Vitamin D, targeting initially the food and nutraceutical markets in Australia and North America.
According to a new estimate from cannabis industry analysts the Brightfield Group, the hemp-CBD market alone could hit $22 billion by 2022. The prospects for Australia are also increasing.
